Detalhe da pesquisa
1.
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Blood
; 135(8): 547-557, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31899794
2.
Erythroferrone inhibits the induction of hepcidin by BMP6.
Blood
; 132(14): 1473-1477, 2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097509
3.
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Proc Natl Acad Sci U S A
; 112(50): 15354-9, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26621728
4.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J Biol Chem
; 291(3): 1267-76, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26515064
5.
Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids.
J Immunol
; 188(1): 322-33, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22131336
6.
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
J Biol Chem
; 287(53): 44425-34, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23148212
7.
Drug use in pregnancy in Ireland's capital city: A decade of trends and outcomes.
Eur J Obstet Gynecol Reprod Biol
; 282: 24-30, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36621262
8.
uPAR-induced cell adhesion and migration: vitronectin provides the key.
J Cell Biol
; 177(5): 927-39, 2007 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17548516
9.
Crystal structure of ultra-humanized anti-pTau Fab reveals how germline substitutions humanize CDRs without loss of binding'.
Sci Rep
; 12(1): 8699, 2022 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610505
10.
Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation.
Antib Ther
; 5(4): 258-267, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36299415
11.
Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns.
MAbs
; 13(1): 1999195, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34780320
12.
Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody.
MAbs
; 13(1): 1883239, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33557673
13.
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
MAbs
; 13(1): 1850395, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459147
14.
In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo.
MAbs
; 12(1): 1755000, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32329655
15.
Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.
J Thromb Haemost
; 18(6): 1278-1290, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32108991
16.
Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation.
Glia
; 57(16): 1802-14, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19459212
17.
A simple high-throughput purification method for hit identification in protein screening.
J Immunol Methods
; 339(1): 38-46, 2008 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18760282
18.
Parallel Evolution of Antibody Affinity and Thermal Stability for Optimal Biotherapeutic Development.
Methods Mol Biol
; 1827: 457-477, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30196511
19.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs
; 10(2): 244-255, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271699
20.
Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens.
Methods Mol Biol
; 1485: 319-338, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27730560